USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: A1AT_HUMAN USC-OGP 2-DE database:  A1AT_HUMAN A1AT_HUMAN General information about the entry View entry in simple text format Entry name A1AT_HUMAN Primary accession number P01009 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Alpha-1-antitrypsin; AltName: Full=Alpha-1 protease inhibitor; AltName: Full=Alpha-1-antiproteinase; AltName: Full=Serpin A1; Contains: RecName: Full=Short peptide from AAT; Short=SPAAT; Flags: Precursor;. Gene name Name=SERPINA1 Synonyms=AAT, PI ORFNames=PRO0684, PRO2209 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0059: pI=4.97; Mw=53960 SPOT OGP-0070: pI=4.86; Mw=51062 Cross-references UniProtKB/Swiss-Prot P01009; A1AT_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name A1AT_HUMAN Primary accession number P01009 Secondary accession number(s) A6PX14 B2RDQ8 Q0PVP5 Q13672 Q53XB8 Q5U0M1 Q7M4R2 Q86U18 Q86U19 Q96BF9 Q96ES1 Q9P1P0 Q9UCE6 Q9UCM3 Sequence was last modified on  October 1, 1996 (version 3) Annotations were last modified on  March 15, 2017 (version 234) Name and origin of the protein Description RecName: Full=Alpha-1-antitrypsin; AltName: Full=Alpha-1 protease inhibitor; AltName: Full=Alpha-1-antiproteinase; AltName: Full=Serpin A1; Contains: RecName: Full=Short peptide from AAT; Short=SPAAT; Flags: Precursor; Gene name Name=SERPINA1 Synonyms=AAT, PI ORFNames=PRO0684, PRO2209 Encoded on Name=SERPINA1; Synonyms=AAT, PI; ORFNames=PRO0684, PRO2209 Keywords 3D-structure; Acute phase; Alternative splicing; Blood coagulation; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Extracellular matrix; Glycoprotein; Hemostasis; Phosphoprotein; Polymorphism; Protease inhibitor; Reference proteome; Secreted; Serine protease inhibitor; Signal. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL K01396; AAB59375.1; -; mRNA EMBL K02212; AAB59495.1; -; Genomic_DNA EMBL X01683; CAA25838.1; -; mRNA EMBL M11465; AAA51546.1; -; mRNA EMBL J02619; AAA51547.1; -; Genomic_DNA EMBL DQ682455; ABG73380.1; -; mRNA EMBL AM048838; CAJ15161.1; -; Genomic_DNA EMBL AF113676; AAF29581.1; -; mRNA EMBL AF130068; AAG35496.1; -; mRNA EMBL BX161449; CAD61914.1; -; mRNA EMBL BX247968; CAD62306.1; -; mRNA EMBL BX248002; CAD62334.1; ALT_INIT; mRNA EMBL BX248257; CAD62585.1; ALT_INIT; mRNA EMBL AK315637; BAG38005.1; -; mRNA EMBL BT019455; AAV38262.1; -; mRNA EMBL BC011991; AAH11991.1; -; mRNA EMBL BC015642; AAH15642.1; -; mRNA EMBL J00064; AAB59369.1; -; Genomic_DNA EMBL J00066; AAB59370.1; -; Genomic_DNA EMBL J00065; AAB59370.1; JOINED; Genomic_DNA EMBL J00067; AAB59371.1; -; Genomic_DNA EMBL X02920; CAA26677.1; -; mRNA EMBL V00496; CAA23755.1; -; mRNA EMBL M26123; AAA51545.1; -; mRNA CCDS CCDS9925.1; -. [P01009-1]; . PIR A21853; ITHU; . PIR A61391; A61391; . RefSeq NP_000286.3; NM_000295.4. [P01009-1]; . RefSeq NP_001002235.1; NM_001002235.2. [P01009-1]; . RefSeq NP_001002236.1; NM_001002236.2. [P01009-1]; . RefSeq NP_001121172.1; NM_001127700.1. [P01009-1]; . RefSeq NP_001121173.1; NM_001127701.1. [P01009-1]; . RefSeq NP_001121174.1; NM_001127702.1. [P01009-1]; . RefSeq NP_001121175.1; NM_001127703.1. [P01009-1]; . RefSeq NP_001121176.1; NM_001127704.1. [P01009-1]; . RefSeq NP_001121177.1; NM_001127705.1. [P01009-1]; . RefSeq NP_001121178.1; NM_001127706.1. [P01009-1]; . RefSeq NP_001121179.1; NM_001127707.1. [P01009-1]; . RefSeq XP_016876859.1; XM_017021370.1. [P01009-1]; . UniGene Hs.525557; -; . PDB 1ATU; X-ray; 2.70 A; A=45-418 PDB 1D5S; X-ray; 3.00 A; A=44-377 B=378-418 PDB; 1EZX; X-ray; 2.60 A A=48-382 B=383-418; PDB; 1HP7; X-ray 2.10 A A=25-418; PDB; 1IZ2; X-ray 2.20 A A=25-418; PDB; 1KCT; X-ray 3.46 A A=25-418; PDB; 1OO8; X-ray 2.65 A A=26-418; PDB; 1OPH; X-ray 2.30 A A=26-418; PDB; 1PSI; X-ray 2.92 A A=26-418; PDB; 1QLP; X-ray 2.00 A A=26-418; PDB; 1QMB; X-ray 2.60 A A=49-376; B=377-418; PDB; 2D26 X-ray 3.30 A; A=25-382; B=383-418; PDB 2QUG X-ray; 2.00 A; A=25-418; PDB 3CWL X-ray; 2.44 A; A=25-418; PDB 3CWM X-ray; 2.51 A; A=25-418; PDB 3DRM X-ray; 2.20 A; A=26-418; PDB 3DRU X-ray; 3.20 A; A/B/C=26-418; PDB 3NDD X-ray; 1.50 A; A=46-382; B=383-418 PDB 3NDF; X-ray; 2.70 A; A=46-382 B=383-418 PDB; 3NE4; X-ray; 1.81 A A=48-418 PDB; 3T1P; X-ray; 3.90 A A=48-418 PDB; 4PYW; X-ray; 1.91 A A=26-418 PDB; 5IO1; X-ray; 3.34 A A/B=29-418 PDB; 7API; X-ray; 3.00 A A=36-382 B=383-418; PDB; 8API; X-ray 3.10 A A=36-382; B=383-418; PDB; 9API X-ray 3.00 A; A=36-382; B=383-418; PDBsum 1ATU -; . PDBsum 1D5S; -; . PDBsum 1EZX; -; . PDBsum 1HP7; -; . PDBsum 1IZ2; -; . PDBsum 1KCT; -; . PDBsum 1OO8; -; . PDBsum 1OPH; -; . PDBsum 1PSI; -; . PDBsum 1QLP; -; . PDBsum 1QMB; -; . PDBsum 2D26; -; . PDBsum 2QUG; -; . PDBsum 3CWL; -; . PDBsum 3CWM; -; . PDBsum 3DRM; -; . PDBsum 3DRU; -; . PDBsum 3NDD; -; . PDBsum 3NDF; -; . PDBsum 3NE4; -; . PDBsum 3T1P; -; . PDBsum 4PYW; -; . PDBsum 5IO1; -; . PDBsum 7API; -; . PDBsum 8API; -; . PDBsum 9API; -; . ProteinModelPortal P01009; -; . SMR P01009; -; . BioGrid 111283; 37; . DIP DIP-35493N; -; . IntAct P01009; 20; . MINT MINT-365327; -; . STRING 9606.ENSP00000348068; -; . DrugBank DB03345; Beta-Mercaptoethanol; . DrugBank DB05481; Recombinant alpha 1-antitrypsin; . MEROPS I04.001; -; . iPTMnet P01009; -; . PhosphoSitePlus P01009; -; . UniCarbKB P01009; -; . BioMuta SERPINA1; -; . DMDM 1703025; -; . DOSAC-COBS-2DPAGE P01009; -; . OGP P01009; -; . REPRODUCTION-2DPAGE IPI00553177; -; . REPRODUCTION-2DPAGE P01009; -; . SWISS-2DPAGE P01009; -; . UCD-2DPAGE P01009; -; . EPD P01009; -; . MaxQB P01009; -; . PaxDb P01009; -; . PeptideAtlas P01009; -; . PRIDE P01009; -; . DNASU 5265; -; . Ensembl ENST00000355814; ENSP00000348068; ENSG00000197249. [P01009-1]; . Ensembl ENST00000393087; ENSP00000376802; ENSG00000197249. [P01009-1]; . Ensembl ENST00000393088; ENSP00000376803; ENSG00000197249. [P01009-1]; . Ensembl ENST00000402629; ENSP00000386094; ENSG00000197249. [P01009-2]; . Ensembl ENST00000404814; ENSP00000385960; ENSG00000197249. [P01009-1]; . Ensembl ENST00000437397; ENSP00000408474; ENSG00000197249. [P01009-1]; . Ensembl ENST00000440909; ENSP00000390299; ENSG00000197249. [P01009-1]; . Ensembl ENST00000448921; ENSP00000416066; ENSG00000197249. [P01009-1]; . Ensembl ENST00000449399; ENSP00000416354; ENSG00000197249. [P01009-1]; . Ensembl ENST00000489769; ENSP00000451525; ENSG00000197249. [P01009-3]; . Ensembl ENST00000636712; ENSP00000490054; ENSG00000197249. [P01009-1]; . GeneID 5265; -; . KEGG hsa:5265; -; . UCSC uc001ycx.5; human. [P01009-1]; . CTD 5265; -; . DisGeNET 5265; -; . GeneCards SERPINA1; -; . GeneReviews SERPINA1; -; . HGNC HGNC:8941; SERPINA1; . HPA CAB013211; -; . HPA CAB016648; -; . HPA CAB073396; -; . HPA HPA000927; -; . HPA HPA001292; -; . MalaCards SERPINA1; -; . MIM 107400; gene; . MIM 613490; phenotype; . neXtProt NX_P01009; -; . OpenTargets ENSG00000197249; -; . Orphanet 60; Alpha-1-antitrypsin deficiency; . Orphanet 178396; Hemorrhagic disease due to alpha-1-antitrypsin Pittsburgh mutation; . PharmGKB PA35509; -; . eggNOG KOG2392; Eukaryota; . eggNOG COG4826; LUCA; . GeneTree ENSGT00760000118839; -; . HOVERGEN HBG005957; -; . InParanoid P01009; -; . KO K03984; -; . OMA NITEMSE; -; . OrthoDB EOG091G0ION; -; . PhylomeDB P01009; -; . TreeFam TF343201; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-204005; COPII (Coat Protein 2) Mediated Vesicle Transport; . Reactome R-HSA-5694530; Cargo concentration in the ER; . Reactome R-HSA-6798695; Neutrophil degranulation; . SIGNOR P01009; -; . ChiTaRS SERPINA1; human; . EvolutionaryTrace P01009; -; . GeneWiki Alpha_1-antitrypsin; -; . GenomeRNAi 5265; -; . PMAP-CutDB P01009; -; . PRO PR:P01009; -; . Proteomes UP000005640; Chromosome 14; . Bgee ENSG00000197249; -; . ExpressionAtlas P01009; baseline and differential; . Genevisible P01009; HS; . GO GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB; . GO GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome; . GO GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; TAS:Reactome; . GO GO:0030134; C:ER to Golgi transport vesicle; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; NAS:UniProtKB; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome; . GO GO:0005794; C:Golgi apparatus; IDA:UniProtKB; . GO GO:0000139; C:Golgi membrane; IEA:GOC; . GO GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA; . GO GO:0031093; C:platelet alpha granule lumen; TAS:Reactome; . GO GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell; . GO GO:0001948; F:glycoprotein binding; IPI:UniProtKB; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0002020; F:protease binding; IPI:UniProtKB; . GO GO:0004867; F:serine-type endopeptidase inhibitor activity; NAS:UniProtKB; . GO GO:0006953; P:acute-phase response; IEA:UniProtKB-KW; . GO GO:0007596; P:blood coagulation; IEA:UniProtKB-KW; . GO GO:0048208; P:COPII vesicle coating; TAS:Reactome; . GO GO:0006888; P:ER to Golgi vesicle-mediated transport; TAS:Reactome; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . InterPro IPR023795; Serpin_CS; . InterPro IPR023796; Serpin_dom; . InterPro IPR000215; Serpin_fam; . PANTHER PTHR11461; PTHR11461; 1; . Pfam PF00079; Serpin; 1; . SMART SM00093; SERPIN; 1; . SUPFAM SSF56574; SSF56574; 1; . PROSITE PS00284; SERPIN; 1; .

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